Wang, Z., Song, C., Hong, X., Yu, J., Xu, Z., Han, P., He, C., Mao, S., Li, Z., Yuan, H., Wang, X., Zhai, J., Tan, S., Fan, W., Xu, Y., Zhang, T., Yang, Z., Lin, S., Zhu, W. ... Xiang, X. (2026).
Reduced eccDNA content in idiopathic asthenozoospermia sperm is associated with compromised DNA repair capacity and elevated DNA damage.
Cellular & Molecular Biology Letters,
31(1), Article 57.
https://doi.org/10.1186/s11658-026-00857-4
Pedersen, A., Blay-Cadanet, J., Storgaard, J., Hernaez, B.
, Thyrsted, J., Bach-Nielsen, C. S., Twayana, K., Jørgensen, S. E., Rio-Bergé, C., Poulsen, C., Thielke, A. L., Thomsen, E. A., Kalucka, J., Olagnier, D., Luo, Y., Reggiori, F., Mogensen, T. H., Alcamí, A.
, Hansen, A. L. & Holm, C. K. (2026).
NRF2 controls a diverse network of antiviral effectors with p62 acting as a central restriction factor effective across virus families.
Redox Biology,
93, Article 104135.
https://doi.org/10.1016/j.redox.2026.104135
AlZaim, I., Hassan, M. N., Schröter, M.
, Mannino, L., Dragicevic, K., Sjogaard, M. B., Festa, J., Dokshokova, L., Weinbrenner, S., Tardajos Ayllon, B.
, Hansen, B., Rasmussen, R. K.
, Christensen, J. N., Wagman, O., Schipper, R., Cai, M., Dheedene, W.
, Bohn, A. B., Farup, J. ... Kalucka, J. (2026).
Defining the vascular niche of human adipose tissue across metabolic states.
Nature Metabolism,
8(3), 722-740.
https://doi.org/10.1038/s42255-026-01475-2
Zhou, T., Zhou, Y.
, Cömert, C., Zhou, X.-Y., Lin, L., Bolund, L., Palmfeldt, J., Luo, Y., Bross, P. & Tong, G. (2026).
Energy metabolism alteration and gene expression reprogramming in a cell model of high fat load non-alcoholic fatty liver disease.
BMC Gastroenterology,
26(1), Article 160.
https://doi.org/10.1186/s12876-026-04658-z
Larsen, A. H., Lin, L., Møller, A. B., Farup, J., Tolbod, L. P., Billeskov, T., Brorson, J., Sundelin, E. I. O., Jakobsen, S., Nørrelund, H., Harms, H. J., Hansson, N. H., Pedersen, S. B., Gormsen, L. C., Luo, Y., de Paoli, F. V., Frøkiær, J., Wiggers, H. & Jessen, N. (2026).
Metformin inhibits proliferation of residing fibroadipogenic progenitor cells from failing human hearts.
ESC Heart Failure,
13(1), Article xvag001.
https://doi.org/10.1093/eschf/xvag001
Ortiz-Bueno, M., Zinghirino, F., Serra, P. P., Paschoudi, K., Montoliu, L., Atilla, E.
, Luo, Y., Cavazza, A., Lederer, C. W. & Benabdellah, K. (2026).
From Bench to Bedside: Ethical and Clinical Best Practices for Genome Editing Applications.
International Journal of Molecular Sciences ,
27(3), Article 1484.
https://doi.org/10.3390/ijms27031484
Lin, L., Jensen, N. M., Delaidelli, A.
, Ferreira, S. A., Yarmahmoudi, F., Sorensen, P. H.
, Romero-Ramos, M., Jensen, P. H., Mackenzie, I. R.
, Nyengaard, J. R. & Jan, A. (2026).
Spatial transcriptomics reveals the molecular signatures of prodromal and advanced α-synucleinopathy.
iScience,
29(3), Article 114845.
https://doi.org/10.1016/j.isci.2026.114845
Han, P., Zhang, C., Ge, F., Liu, C., Fu, J.
, Lv, W., Jin, X., Zhang, J., Zhao, L.
, Luo, Y., Su, X. & Lan, X. (2025).
Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia.
Computational and Structural Biotechnology Journal,
27, 2602-2613.
https://doi.org/10.1016/j.csbj.2025.06.020
Damsgaard, C., Viuf Skøtt, M., Williams, C., Malte, H., Kidmose, C. K., Busk, M., Dedek, K.
, Konradsen, A. H., Rasmussen, A. S. S., Thomsen, J. S., Mikkelsen, A. V. G. T.
, Johannsen, K. S., Vendelbo, M., Revsbech, N. P., Elemans, C. P. H., Mouritsen, H.
, Kalucka, J. M., Lin, L., Iversen, N. K. ... Nyengaard, J. R. (2026).
Oxygen-free metabolism in the bird inner retina supported by the pecten.
Nature,
650(8102), 657–663.
https://doi.org/10.1038/s41586-025-09978-w
Ogurlu, B., van Furth, L. A., Zuo, Y., Hamelink, T. L., van Klinken, J. B., Pamplona, C. C.
, Bennedsgaard, S. S., van Leeuwen, L. L., Lantinga, V. A.
, Qi, H., Pool, M. B. F., Vendrell, I., Kessler, B. M., Fischer, R.
, Lin, L., Luo, Y., Jespersen, B., van Dijk, K. W., Bakker, B. M. ... Moers, C. (2025).
Kidney Metabolism During Normothermic Machine Perfusion Differs Substantially From In Vivo Conditions.
Transplantation,
110(2), e405-e415. Article 10.1097/TP.0000000000005586.
https://doi.org/10.1097/TP.0000000000005586
Chen, L.
, Li, H., Teng, J., Wang, Z., Qu, X., Chen, Z., Cai, X., Zeng, H.
, Bai, Z., Li, J., Pan, X., Yan, L.
, Wang, F., Lin, L., Luo, Y., Sahana, G., Lund, M. S., Ballester, M., Crespo-Piazuelo, D. ... Yi, G. (2026).
Construction of a Multitissue Cell Atlas Reveals Cell-Type-Specific Regulation of Molecular and Complex Phenotypes in Pigs.
Advanced Science,
13(8), Article e04961.
https://doi.org/10.1002/advs.202504961
Sun, Y., Qu, K., Corsi, G. I., Anthon, C., Pan, X., Xiang, X.
, Jensen, L. J., Lin, L., Luo, Y. & Gorodkin, J. (2025).
Deep learning models simultaneously trained on multiple datasets improve base-editing activity prediction.
Nature Communications,
16(1), Article 9821.
https://doi.org/10.1038/s41467-025-65200-5
Ahlgreen, O. A., Hansen, M. W., Baake, J., Hybel, T. E., Rossi, R., Lai, X., Sankaranarayanan, I.
, Pold, J. A., Lin, L., Reinert, L., Paludan, S. R., Price, T. J.
, Pallesen, L. T. & Vægter, C. B. (2026).
Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion.
Advanced Science,
13(1), Article e11569.
https://doi.org/10.1002/advs.202511569
Han, B.
, Li, H., Zheng, W., Zhang, Q., Chen, A., Zhu, S., Shi, T., Wang, F., Zou, D., Song, Y., Ye, W., Du, A., Fu, Y., Jia, M.
, Bai, Z., Yuan, Z., Liu, W., Tuo, W., Hope, J. C. ... Sun, D. (2025).
A multi-tissue single-cell expression atlas in cattle.
Nature Genetics,
57(10), 2546-2561.
https://doi.org/10.1038/s41588-025-02329-5
AlZaim, I., Hassan, M. N., Schröter, M.
, Mannino, L., Dragicevic, K., Sjogaard, M. B., Festa, J., Dokshokova, L., Weinbrenner, S., Tardajos Ayllon, B.
, Hansen, B., Rasmussen, R. K., Christensen, J. N., Wagman, O., Schipper, R., Cai, M., Dheedene, W.
, Bohn, A. B., Farup, J. ... Kalucka, J. (2025).
Defining the vascular niche of human adipose tissue across metabolic states. bioRxiv.
https://doi.org/10.1101/2024.09.22.610444
García-Rodríguez, J. L., Korsgaard, U., Vissing, S. M., Paasch, T. P., Semenova, M., Vendelbo, S. L.
, Jensby, E. F., Williams, H. L.
, Salachan, P. V., Brandt, C. B., Hanimann, J.
, Lin, L., Zlobec, I.
, Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2025).
Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer.
Communications Biology,
8(1), Article 1345.
https://doi.org/10.1038/s42003-025-08799-x
Fonager, S. V., Winther, G., Weber, Y. C. L., Wittenborn, T. R., Kastberg, K. S., Terczyńska-Dyla, E., Jensen, L., Hansen, L. A., Carroll, M. C.
, Luo, Y., Lin, L. & Degn, S. E. (2025).
Maternal imprinting of autoreactivity in a murine model of systemic lupus erythematosus.
Brain, Behavior, and Immunity,
129, 921-934.
https://doi.org/10.1016/j.bbi.2025.07.025
Koning, M., Dumas, S. J., Meta, E., Lievers, E., de Graaf, A. M. A., Borri, M., Nai Chung Tong, L. J., Liang, X., Liu, P., Chen, F.
, Lin, L., Luo, Y., Carmeliet, P., van den Berg, C. W. & Rabelink, T. J. (2025).
Single cell transcriptomics of human kidney organoid endothelium reveals vessel growth processes and arterial maturation upon transplantation.
npj Regenerative Medicine,
10(1), Article 32.
https://doi.org/10.1038/s41536-025-00418-x
Li, C., Lv, W., He, Z., Pan, X., Zeng, Y., Mulder, J., Sjöstedt, E., Huang, Z., Liu, W., Xu, L., Eisenberg, E.
, Lin, L., Hansen, J. B., Huang, J.
& Luo, Y. (2025).
Landscape of A-I RNA editing in mouse, pig, macaque, and human brains.
Nucleic Acids Research,
53(11), Article gkaf534.
https://doi.org/10.1093/nar/gkaf534
Shi, M., Méar, L., Karlsson, M., Álvez, M. B., Digre, A., Schutten, R., Katona, B., Vuu, J., Lindström, E., Hikmet, F., Jin, H., Yuan, M., Li, X., Yang, H., Song, X., Sjöstedt, E., Edfors, F., Oksvold, P., von Feilitzen, K. ... Zhang, C. (2025).
A resource for whole-body gene expression map of human tissues based on integration of single cell and bulk transcriptomics.
Genome Biology,
26(1), 152. Article 152.
https://doi.org/10.1186/s13059-025-03616-4
Ding, X., Lai, X., Klaestrup, I. H., Jensen, S. R. N., Nielsen, M. M., Thorsen, K., Romero-Ramos, M., Luo, Y., Lin, L., Reinert, L. S. & Paludan, S. R. (2025).
Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection.
Journal of Neuroinflammation,
22(1), Article 146.
https://doi.org/10.1186/s12974-025-03471-x
Brorson, J., Lin, L., Wang, J., Bæk, A., Billeskov, T. B., Thybo, F. F., Just, J., Haskó, J., Ravn, C., Hansen, R. L., Bue, M., Jørgensen, J. O. L., Luo, Y., Jessen, N. & Farup, J. (2025).
Complementing muscle regeneration-fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle.
Nature Communications,
16(1), Article 5233.
https://doi.org/10.1038/s41467-025-60627-2
Yuan, H.
, Song, C., Xu, H., Sun, Y., Anthon, C.
, Bolund, L., Lin, L., Benabdellah, K., Lee, C., Hou, Y., Gorodkin, J.
& Luo, Y. (2025).
An Overview and Comparative Analysis of CRISPR-SpCas9 gRNA Activity Prediction Tools.
The CRISPR Journal,
8(2), 89-104.
https://doi.org/10.1089/crispr.2024.0058
Hansen, L. M. B., Dam, V. S., Guldbrandsen, H. Ø., Staehr, C., Pedersen, T. M., Kalucka, J. M., Beck, H. C.
, Postnov, D., Lin, L. & Matchkov, V. (2025).
Spatial Transcriptomics and Proteomics Profiling After Ischemic Stroke Reperfusion: Insights Into Vascular Alterations.
Stroke,
56(4), 1036-1047.
https://doi.org/10.1161/STROKEAHA.124.048085
Lv, W., Zeng, Y., Li, C., Liang, Y., Tao, H., Zhu, Y., Sui, X., Li, Y., Jiang, S., Gao, Q., Rodriguez-Fos, E., Prasad, G., Wang, Y., Zhou, R., Xu, Z., Pan, X., Chen, L.
, Xiang, X., Teng, H. ... Han, P. (2025).
Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment.
Cancer Discovery,
15(6), 1225-1246.
https://doi.org/10.1158/2159-8290.CD-24-1532
Liang, X., Arrey, G., Qin, Y., Álvarez-González, L., Hariprakash, J. M., Ma, J., Holt, S., Han, P.
, Luo, Y., Li, H., Ruiz-Herrera, A., Pilegaard, H. & Regenberg, B. (2025).
EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA formation.
Nature Communications,
16(1), 1872. Article 1872.
https://doi.org/10.1038/s41467-025-57042-y
Cavazza, A., Molina-Estévez, F. J., Reyes, Á. P., Ronco, V., Naseem, A., Malenšek, Š., Pečan, P., Santini, A., Heredia, P., Aguilar-González, A., Boulaiz, H., Ni, Q., Cortijo-Gutierrez, M., Pavlovic, K., Herrera, I., de la Cerda, B., Garcia-Tenorio, E. M., Richard, E., Granados-Principal, S. ... Benabdellah, K. (2025).
Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group.
Molecular Therapy Nucleic Acids,
36(1), Article 102457.
https://doi.org/10.1016/j.omtn.2025.102457
Zeng, Y.
, Lv, W., Tao, H., Li, C., Jiang, S., Liang, Y., Chen, C., Yu, T., Li, Y., Wu, S., Cui, X., Liang, N., Wang, P.
, Xu, H., Dong, J., Teng, H., Chen, K., Mu, K., Fan, T. ... Han, P. (2025).
Mapping the chromothripsis landscape in urothelial carcinoma unravels great intratumoral and intertumoral heterogeneity.
iScience,
28(1), 111510. Article 111510.
https://doi.org/10.1016/j.isci.2024.111510
Gultom, M.
, Lin, L., Brandt, C. B., Milusev, A., Despont, A., Shaw, J., Döring, Y.
, Luo, Y. & Rieben, R. (2025).
Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells.
Inflammation,
48(4), 2531–2547.
https://doi.org/10.1007/s10753-024-02208-x
Madan, E., Palma, A. M., Vudatha, V., Kumar, A., Bhoopathi, P., Wilhelm, J., Bernas, T., Martin, P. C., Bilolikar, G., Gogna, A., Peixoto, M. L., Dreier, I., Araujo, T. F., Garre, E., Gustafsson, A., Dorayappan, K. D. P., Mamidi, N., Sun, Z., Yekelchyk, M. ... Gogna, R. (2025).
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells.
Nature Biotechnology,
43(11), 1833-1847. Article e13714.
https://doi.org/10.1038/s41587-024-02453-3
Liang, L., Chai, C., Liu, A.
, Nadukkandy, A. S., Kalaiselvan, S., Brandt, C. B., Zhao, W., Li, H.
, Lin, L., Wu, J.
& Luo, Y. (2024).
Single-cell transcriptome analysis reveals reciprocal epithelial and endothelial cell evolution in ovarian cancer.
iScience,
27(12), Article 111417.
https://doi.org/10.1016/j.isci.2024.111417
Yuan, H., Song, Z., Sun, X.-Q.
, Song, C., Guo, L., Zhang, Q.
, Luo, Y., Yuan, C., Gao, J. & Jia, X. (2025).
Profiling the cell diversity and tissue structure of aqueous humor circulatory system in human eyes using spatial single-cell RNA sequencing.
Genes & diseases,
12(1), 101304. Article 101304.
https://doi.org/10.1016/j.gendis.2024.101304
Lv, W., Pan, X., Han, P., Wu, S., Zeng, Y., Wang, Q., Guo, L., Xu, M., Qi, Y., Deng, L., Xu, Z., Li, C., Yu, T., Cui, X., Teng, H., Xiang, C., Tan, H., Li, Y., Liang, N.
... Luo, Y. (2024).
Extrachromosomal circular DNA orchestrates genome heterogeneity in urothelial bladder carcinoma.
Theranostics,
14(13), 5102-5122.
https://doi.org/10.7150/thno.99563
Gál, Z., Boukoura, S., Oxe, K. C., Badawi, S., Nieto, B., Korsholm, L. M., Geisler, S. B., Dulina, E., Rasmussen, A. V.
, Dahl, C., Lv, W., Xu, H., Pan, X., Arampatzis, S., Stratou, D.-E., Galanos, P.
, Lin, L., Guldberg, P., Bartek, J. ... Larsen, D. H. (2024).
Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation.
Nature Communications,
15(1), Article 7797.
https://doi.org/10.1038/s41467-024-52189-6
Cömert, C., Kjær-Sørensen, K., Hansen, J., Carlsen, J., Just, J., Meaney, B. F., Østergaard, E.
, Luo, Y., Oxvig, C., Schmidt-Laursen, L., Palmfeldt, J., Fernandez-Guerra, P. & Bross, P. (2024).
HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis.
Molecular Metabolism,
88, Article 102009.
https://doi.org/10.1016/j.molmet.2024.102009
Cham, L. B., Rosas-Umbert, M., Lin, L., Tolstrup, M. & Søgaard, O. S. (2024).
Single-Cell Analysis Reveals That CD47 mRNA Expression Correlates with Immune Cell Activation, Antiviral Isgs, and Cytotoxicity.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
58(4), 322-335.
https://doi.org/10.33594/000000715
Lebas, M., Chinigò, G., Courmont, E., Bettaieb, L., Machmouchi, A., Goveia, J., Beatovic, A., Van Kerckhove, J., Robil, C., Angulo, F. S., Vedelago, M., Errerd, A., Treps, L., Gao, V., Delgado De la Herrán, H. C., Mayeuf-Louchart, A., L'homme, L., Chamlali, M., Dejos, C. ... Cantelmo, A. R. (2024).
Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition.
Science Advances,
10(32), eadp6182. Article adp6182.
https://doi.org/10.1126/sciadv.adp6182
Recknagel, H., Močivnik, L., Zakšek, V.
, Luo, Y., Kostanjšek, R. & Trontelj, P. (2024).
Generation of genome-wide SNP markers from minimally invasive sampling in endangered animals and applications in species ecology and conservation.
Molecular Ecology Resources,
24(7), Article e13995.
https://doi.org/10.1111/1755-0998.13995
Zhou, M.
, Lv, W., Han, P., Sun, K., Hao, Z., Gao, L., Xu, Y., Xu, Z., Shao, S., Ma, S., Guo, Q., Zhang, H., Liu, K., Yang, F., Yuan, Z., Wu, G., Yu, C.
, Luo, Y., Yao, Z. & Zhao, J. (2024).
Plasma extrachromosomal circular DNA as a potential diagnostic biomarker for nodular thyroid disease.
Clinical and Translational Medicine,
14(6), e1740.
https://doi.org/10.1002/ctm2.1740
Berggreen, A. H.
, Petersen, J. L., Lin, L., Benabdellah, K.
& Luo, Y. (2023).
CRISPR delivery with extracellular vesicles: Promises and challenges.
Journal of Extracellular Biology,
2(9), e111. Article e111.
https://doi.org/10.1002/jex2.111
Ma, W., Zhong, X., Cai, B., Shao, M., Yu, X., Lv, M., Xu, S., Zhan, B., Li, Q., Ma, M.
, Kjær, M. B., Huang, J.
, Luo, Y., Grønbæk, H. & Lin, L. (2023).
Unveiling the pathogenesis of non-alcoholic fatty liver disease by decoding biomarkers through integrated single-cell and single-nucleus profiles.
https://doi.org/10.1101/2023.10.05.23296635
Ma, W., Huang, J., Cai, B., Shao, M., Yu, X.
, Kjær, M. B., Lv, M., Zhong, X., Xu, S., Zhan, B., Li, Q., Huang, Q., Ma, M., Cheng, L.
, Luo, Y., Grønbæk, H., Zhou, X. & Lin, L. (2024).
A gene-based clustering approach reveals QSOX1/IL1RAP as promising biomarkers for the severity of non-alcoholic fatty liver disease.
https://doi.org/10.1101/2023.07.26.23293038
Kragh, P. M., Nielsen, A. L., Li, J., Du, Y., Lin, L., Schmidt, M., Bøgh, I. B.
, Holm, I. E., Jakobsen, J. E., Johansen, M. G., Purup, S., Bolund, L., Vajta, G. & Jørgensen, A. L. (2009).
Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw.
Transgenic Research,
18(4), 545-58.
https://doi.org/10.1007/s11248-009-9245-4
Huang, F., Lyu, B., Xie, F., Li, F., Xing, Y., Han, Z., Lai, J., Ma, J., Zou, Y., Zeng, H., Xu, Z., Gao, P.
, Luo, Y., Bolund, L., Tong, G. & Fengping, X. (2024).
From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients.
Frontiers in Microbiology,
15, Article 1366744.
https://doi.org/10.3389/fmicb.2024.1366744