Selected publications

Wang, F., Ding, P., Liang, X., Ding, X., Brandt, C. B., Sjöstedt, E., Zhu, J., Bolund, S., Zhang, L., de Rooij, L., Luo, L., Wei, Y., Zhao, W., Lv, Z., Haskó, J., Li, R., Qin, Q., Jia, Y., Wu, W., Yuan, Y., … Luo, Y. (2022). Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level. Nature communications, 13 (1), 3620. doi.org/10.1038/s41467-022-31388-z

Noer JB, Hørsdal OK, Xiang X, Luo Y, Regenberg B. Extrachromosomal circular DNA in cancer: history, current knowledge, and methods. Trends Genet. 2022 Mar 8:S0168-9525(22)00034-8. doi: 10.1016/j.tig.2022.02.007. Epub ahead of print. PMID: 35277298. (This review provides a comprehensive summary of the eccDNA and its roles in cancers.)

Corsi GI, Qu K, Alkan F, Pan X, Luo Y, Gorodkin J. CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context. Nat Commun. 2022 May 30;13(1):3006. doi: 10.1038/s41467-022-30515-0. PMID: 35637227; PMCID: PMC9151727.

Karlsson M, Sjöstedt E, Oksvold P, Sivertsson Å, Huang J, Álvez MB, Arif M, Li X, Lin L, Yu J, Ma T, Xu F, Han P, Jiang H, Mardinoglu A, Zhang C, von Feilitzen K, Xu X, Wang J, Yang H, Bolund L, Zhong W, Fagerberg L, Lindskog C, Pontén F, Mulder J, Luo Y, Uhlen M. Genome-wide annotation of protein-coding genes in pig. BMC Biol. 2022 Jan 25;20(1):25. doi: 10.1186/s12915-022-01229-y. PMID: 35073880; PMCID: PMC8788080. (The first body-wide classification of protein coding gene expression in pig tissues and organs)

Xiang X, Corsi GI, Anthon C, Qu K, Pan X, Liang X, Han P, Dong Z, Liu L, Zhong J, Ma T, Wang J, Zhang X, Jiang H, Xu F, Liu X, Xu X, Wang J, Yang H, Bolund L, Church GM, Lin L, Gorodkin J, Luo Y. Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning. Nat Commun. 2021 May 28;12(1):3238. doi: 10.1038/s41467-021-23576-0. PMID: 34050182; PMCID: PMC8163799. (This study reports the CRISPRTRAP-seq method for high throughput quantification of CRISPR gRNA activity in cells. The study also reported the generation of new deep learning based tool, CRISPRon, for prediction of CRISPR on-target targeting activity.)

Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C. A single-cell type transcriptomics map of human tissues. Sci Adv. 2021 Jul 28;7(31):eabh2169. doi: 10.1126/sciadv.abh2169. PMID: 34321199; PMCID: PMC8318366. (A single cell type gene expression atlas in human tissues. This study integrate single cell RNA sequencing results to classify the gene expression specificity in single cell type levels)

Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J. An atlas of the protein-coding genes in the human, pig, and mouse brain. Science. 2020 Mar 6;367(6482):eaay5947. doi: 10.1126/science.aay5947. PMID: 32139519. (This study reported the first systematic classification of gene expression specificity and distribution of all protein-coding genes in the mouse, pig and human brain.)

Kalucka J, de Rooij LPMH, Goveia J, Rohlenova K, Dumas SJ, Meta E, Conchinha NV, Taverna F, Teuwen LA, Veys K, García-Caballero M, Khan S, Geldhof V, Sokol L, Chen R, Treps L, Borri M, de Zeeuw P, Dubois C, Karakach TK, Falkenberg KD, Parys M, Yin X, Vinckier S, Du Y, Fenton RA, Schoonjans L, Dewerchin M, Eelen G, Thienpont B, Lin L, Bolund L, Li X, Luo Y, Carmeliet P. Single-Cell Transcriptome Atlas of Murine Endothelial Cells. Cell. 2020 Feb 20;180(4):764-779.e20. doi: 10.1016/j.cell.2020.01.015. Epub 2020 Feb 13. PMID: 32059779. (This study reported the first investigation of EC heterogeneity in mouse tissues/organs using single cell transcriptome analysis)

Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang G, Luo Y, Qing Y, Jiao D, Zhao H, Zhou X, Wang S, Wei H, Güell M, Church GM, Yang L. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science. 2017 Sep 22;357(6357):1303-1307. doi: 10.1126/science.aan4187. Epub 2017 Aug 10. PMID: 28798043; PMCID: PMC5813284. (The first PERV inactivated pigs were generated by CRISPR and cloning.)

Full publications

Zheng, T., Huang, J., Xiang, X., Li, S., Yu, J., Qu, K., Xu, Z., Han, P., Dong, Z., Liu, Y., Xu, F., Yang, H., Jäättelä, M., Luo, Y. & Liu, B. (2021). Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes. Cancer Cell International, 21(1), Article 530. https://doi.org/10.1186/s12935-021-02224-z

Berthelsen, M. F., Riedel, M., Cai, H., Skaarup, S. H., Alstrup, A. K. O., Dagnæs-Hansen, F., Luo, Y., Jensen, U. B., Hager, H., Liu, Y., Callesen, H., Vendelbo, M. H., Jakobsen, J. E. & Thomsen, M. K. (2021). The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues. Cancers, 13(12), Article 3024. https://doi.org/10.3390/cancers13123024

Zhang, C., Li, C., Yang, L., Leng, L., Jovic, D., Wang, J., Fang, F., Li, G., Zhao, D., Li, X., Lin, L., Luo, Y., Bolund, L., Huang, J., Lin, G. & Xu, F. (2021). The Dynamic Changes of Transcription Factors During the Development Processes of Human Biparental and Uniparental Embryos. Frontiers in Cell and Developmental Biology, 9, Article 709498. https://doi.org/10.3389/fcell.2021.709498

Teuwen, L. A., De Rooij, L. P. M. H., Cuypers, A., Rohlenova, K., Dumas, S. J., García-Caballero, M., Meta, E., Amersfoort, J., Taverna, F., Becker, L. M., Veiga, N., Cantelmo, A. R., Geldhof, V., Conchinha, N. V., Kalucka, J., Treps, L., Conradi, L. C., Khan, S., Karakach, T. K. ... Carmeliet, P. (2021). Tumor vessel co-option probed by single-cell analysis. Cell Reports, 35(11), Article 109253. https://doi.org/10.1016/j.celrep.2021.109253

Arslanova, A., Shafaattalab, S., Ye, K., Asghari, P., Lin, L., Kim, B. R., Roston, T. M., Hove-Madsen, L., Van Petegem, F., Sanatani, S., Moore, E., Lynn, F., Søndergaard, M., Luo, Y., Chen, S. R. W. & Tibbits, G. F. (2021). Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia. Current protocols, 1(12), Article e320. https://doi.org/10.1002/cpz1.320

Sjöstedt, E., Zhong, W., Fagerberg, L., Karlsson, M., Mitsios, N., Adori, C., Oksvold, P., Edfors, F., Limiszewska, A., Hikmet, F., Huang, J., Du, Y., Lin, L., Dong, Z., Yang, L., Liu, X., Jiang, H., Xu, X., Wang, J. ... Mulder, J. (2020). An atlas of the protein-coding genes in the human, pig, and mouse brain. Science, 367(6482), Article 5947. https://doi.org/10.1126/science.aay5947

Goveia, J., Rohlenova, K., Taverna, F., Treps, L., Conradi, L.-C., Pircher, A., Geldhof, V., de Rooij, L. P. M. H., Kalucka, J., Sokol, L., García-Caballero, M., Zheng, Y., Qian, J., Teuwen, L.-A., Khan, S., Boeckx, B., Wauters, E., Decaluwé, H., De Leyn, P. ... Carmeliet, P. (2020). An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. Cancer Cell, 37(1), 21-36.e13. https://doi.org/10.1016/j.ccell.2019.12.001

Wang, J., Zhang, X., Cheng, L. & Luo, Y. (2020). An overview and metanalysis of Machine and Deep Learning-Based CRISPR gRNA Design Tools. RNA Biology, 17(1), 13-22. https://doi.org/10.1080/15476286.2019.1669406

Olagnier, D., Farahani, E., Thyrsted, J., Blay-Cadanet, J., Herengt, A., Idorn, M., Hait, A., Hernaez, B., Knudsen, A., Iversen, M. B., Schilling, M., Jørgensen, S. E., Thomsen, M., Reinert, L. S., Lappe, M., Hoang, H.-D., Gilchrist, V. H., Hansen, A. L., Ottosen, R. ... Holm, C. K. (2020). Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature Communications, 11(1), Article 5419. https://doi.org/10.1038/s41467-020-19363-y

Feng, L., Chao, J., Tian, E., Li, L., Ye, P., Zhang, M., Chen, X., Cui, Q., Sun, G., Zhou, T., Felix, G., Qin, Y., Li, W., Meza, E. D., Klein, J., Ghoda, L., Hu, W., Luo, Y., Dang, W. ... Shi, Y. (2020). Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs. Advanced Science, 7(23), Article 2002155. https://doi.org/10.1002/advs.202002155

Larsen, M. T., Mandrup, O. A., Schelde, K. K., Luo, Y., Sørensen, K. D., Dagnæs-Hansen, F., Cameron, J., Stougaard, M., Steiniche, T. & Howard, K. A. (2020). FcRn overexpression in human cancer drives albumin recycling and cell growth: a mechanistic basis for exploitation in targeted albumin-drug designs. Journal of Controlled Release, 322, 53-63. https://doi.org/10.1016/j.jconrel.2020.03.004

Luo, L., Zhou, Y., Zhang, C., Huang, J., Du, J., Liao, J., Bergholt, N. L., Bünger, C., Xu, F., Lin, L., Tong, G., Zhou, G. & Luo, Y. (2020). Feeder-free generation and transcriptome characterization of functional mesenchymal stromal cells from human pluripotent stem cells. Stem Cell Research, 48, Article 101990. https://doi.org/10.1016/j.scr.2020.101990

Wang, J., Xiang, X., Bolund, L., Zhang, X., Cheng, L. & Luo, Y. (2020). GNL-Scorer: A generalized model for predicting CRISPR on-target activity by machine learning and featurization. Molecular and Cellular Biology, 12(11), 909-911. https://doi.org/10.1093/jmcb/mjz116

Yu, J., Xiang, X., Huang, J., Liang, X., Pan, X., Dong, Z., Petersen, T. S., Qu, K., Yang, L., Zhao, X., Li, S., Zheng, T., Xu, Z., Liu, C., Han, P., Xu, F., Yang, H., Liu, X., Zhang, X. ... Lin, L. (2020). Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing. Nucleic Acids Research, 48(5), Article e25. https://doi.org/10.1093/nar/gkz1233

Björkman, A., Johansen, S. L., Lin, L., Schertzer, M., Kanellis, D. C., Katsori, A.-M., Christensen, S. T., Luo, Y., Andersen, J. S., Elsässer, S. J., Londono-Vallejo, A., Bartek, J. & Schou, K. B. (2020). Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution. Genes & Development, 34(15-16), 1065-1074. https://doi.org/10.1101/gad.330050.119

Han, P., Wei, G., Cai, K., Xiang, X., Deng, W. P., Li, Y. B., Kuang, S., Dong, Z., Zheng, T., Luo, Y., Liu, J., Guan, Y., Li, C., Dey, S. K., Liao, Z. & Banerjee, S. (2020). Identification and functional characterization of mutations in LPL gene causing severe hypertriglyceridaemia and acute pancreatitis. Journal of Cellular and Molecular Medicine (Online), 24(2), 1286-1299. https://doi.org/10.1111/jcmm.14768

Thomsen, E. A., Rovsing, A. B., Anderson, M. V., Due, H., Huang, J., Luo, Y., Dybkaer, K. & Mikkelsen, J. G. (2020). Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma. Molecular Oncology, 14(9), 1978-1997. https://doi.org/10.1002/1878-0261.12753

Liu, T., Li, J., Dou, H., Xiang, X., Chen, W., Zhang, T., Li, L., Zhang, X., Dong, X., Chen, L., Lin, X., Li, J., Sun, H.-X., Gu, Y. & Lin, L. (2020). Low-Concentration Essential Amino Acids in PZM-3 Improve the Developmental Competence of Porcine Embryos Produced by Handmade Cloning. Cellular reprogramming, 22(6), 282-290. https://doi.org/10.1089/cell.2020.0036

Nelson, S. R., Zhang, C., Roche, S., O'Neill, F., Swan, N., Luo, Y., Larkin, A., Crown, J. & Walsh, N. (2020). Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development. Scientific Reports, 10(1), Article 2778. https://doi.org/10.1038/s41598-020-59368-7

Olagnier, D., Farahani, E., Thyrsted, J., Blay-Cadanet, J., Herengt, A., Idorn, M., Hait, A., Hernaez, B., Knudsen, A., Iversen, M. B., Schilling, M., Jørgensen, S. E., Thomsen, M., Reinert, L. S., Lappe, M., Hoang, H.-D., Gilchrist, V. H., Hansen, A. L., Ottosen, R. ... Holm, C. K. (2020). SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature Communications, 11(1), Article 4938. https://doi.org/10.1038/s41467-020-18764-3

Rohlenova, K., Goveia, J., García-Caballero, M., Subramanian, A., Kalucka, J., Treps, L., Falkenberg, K. D., de Rooij, L. P. M. H., Zheng, Y., Lin, L., Sokol, L., Teuwen, L.-A., Geldhof, V., Taverna, F., Pircher, A., Conradi, L.-C., Khan, S., Stegen, S., Panovska, D. ... Carmeliet, P. (2020). Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis. Cell Metabolism, 31(4), 862-877.e14. https://doi.org/10.1016/j.cmet.2020.03.009

Dumas, S. J., Meta, E., Borri, M., Goveia, J., Rohlenova, K., Conchinha, N. V., Falkenberg, K., Teuwen, L.-A., de Rooij, L., Kalucka, J., Chen, R., Khan, S., Taverna, F., Lu, W., Parys, M., De Legher, C., Vinckier, S., Karakach, T. K., Schoonjans, L. ... Carmeliet, P. (2020). Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation. Journal of the American Society of Nephrology : JASN, 31(1), 118-138. https://doi.org/10.1681/ASN.2019080832

Kalucka, J., de Rooij, L. P. M. H., Goveia, J., Rohlenova, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L.-A., Veys, K., García-Caballero, M., Khan, S., Geldhof, V., Sokol, L., Chen, R., Treps, L., Borri, M., de Zeeuw, P., Dubois, C. ... Carmeliet, P. (2020). Single-Cell Transcriptome Atlas of Murine Endothelial Cells. Cell, 180(4), 764-779.e20. https://doi.org/10.1016/j.cell.2020.01.015

Xiang, X., Li, C., Chen, X., Dou, H., Li, Y., Zhang, X. & Luo, Y. (2019). CRISPR/Cas9-Mediated Gene Tagging: A Step-by-Step Protocol. In Y. Luo (Ed.), Methods in Molecular Biology (pp. 255-269). Humana Press. https://doi.org/10.1007/978-1-4939-9170-9_16

Korsholm, L. M., Gál, Z., Lin, L., Quevedo, O., Ahmad, D. A., Dulina, E., Luo, Y., Bartek, J. & Larsen, D. H. (2019). Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair. Nucleic Acids Research, 47(15), 8019-8035. https://doi.org/10.1093/nar/gkz518

Lin, L. & Luo, Y. (2019). Functional Evaluation of CRISPR Activity by the Dual-Fluorescent Surrogate System: C-Check. In Y. Luo (Ed.), Methods in Molecular Biology: Methods and Protocols (pp. 67-77). Springer Science+Business Media. https://doi.org/10.1007/978-1-4939-9170-9_5

Mikkelsen, R. B., Frederiksen, H. R. S., Gjerris, M., Holst, B., Hyttel, P., Luo, Y., Freude, K. & Sandøe, P. (2019). Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing. The CRISPR Journal, 2(6), 362-369. https://doi.org/10.1089/crispr.2019.0024

Xiang, X., Luo, L., Nodzyński, M., Li, C., Han, P., Dou, H., Petersen, T. S., Liang, X., Pan, X., Qu, K., Yang, L., Dang, Y., Liu, X., Bolund, L., Zhang, X., Tong, G., Xing, Y., Luo, Y. & Lin, L. (2019). LION: a simple and rapid method to achieve CRISPR gene editing. Cellular and Molecular Life Sciences, 76(13), 2633-2645. https://doi.org/10.1007/s00018-019-03064-x

Gostinčar, C., Sun, X., Zajc, J., Fang, C., Hou, Y., Luo, Y., Gunde-Cimerman, N. & Song, Z. (2019). Population Genomics of an Obligately Halophilic Basidiomycete Wallemia ichthyophaga. Frontiers in Microbiology, 10. https://doi.org/10.3389/fmicb.2019.02019

Neldeborg, S., Lin, L., Stougaard, M. & Luo, Y. (2019). Rapid and Efficient Gene Deletion by CRISPR/Cas9. In Methods in Molecular Biology: Methods and Protocols (pp. 233-247). Humana Press. https://doi.org/10.1007/978-1-4939-9170-9_14

Luo, Y. (2019). Refining CRISPR-based genome and epigenome editing off-targets. Cell Biology and Toxicology, 35(4), 281-283. https://doi.org/10.1007/s10565-019-09482-8

Leng, L., Sun, J., Huang, J., Gong, F., Yang, L., Zhang, S., Yuan, X., Fang, F., Xu, X., Luo, Y., Bolund, L., Peters, B. A., Lu, G., Jiang, T., Xu, F. & Lin, G. (2019). Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development. Cell Stem Cell, 25(5), 697-712.e6. https://doi.org/10.1016/j.stem.2019.09.004

Jensen, I. S., Yuan, J., He, J., Lin, L., Sander, B. & Golas, M. M. (2019). The FlpTRAP system for purification of specific, endogenous chromatin regions. Analytical Biochemistry, 587, Article 113418. https://doi.org/10.1016/j.ab.2019.113418

Falkenberg, K. D., Rohlenova, K., Luo, Y. & Carmeliet, P. (2019). The metabolic engine of endothelial cells. Nature Metabolism, 1(10), 937-946. https://doi.org/10.1038/s42255-019-0117-9

Lin, L. & Luo, Y. (2019). Tracking CRISPR's Footprints. In Y. Luo (Ed.), Methods in Molecular Biology: Methods and Protocols (pp. 13-28). Springer Science+Business Media. https://doi.org/10.1007/978-1-4939-9170-9_2

Chen, M., Laursen, S. H., Habekost, M., Knudsen, C. H., Buchholdt, S. H., Huang, J., Xu, F., Liu, X., Bolund, L., Luo, Y., Nissen, P., Febbraro, F. & Denham, M. (2018). Central and peripheral nervous system progenitors derived from human pluripotent stem cells reveal a unique temporal and cell-type specific expression of PMCAs. Frontiers in Cell and Developmental Biology, 6, Article 5. https://doi.org/10.3389/fcell.2018.00005

Møller, H. D., Lin, L., Xiang, X., Petersen, T. S., Huang, J., Yang, L., Kjeldsen, E., Jensen, U. B., Zhang, X., Liu, X., Xu, X., Wang, J., Yang, H., Church, G. M., Bolund, L., Regenberg, B. & Luo, Y. (2018). CRISPR-C: circularization of genes and chromosome by CRISPR in human cells. Nucleic Acids Research, 46(22), e131. Article e131. https://doi.org/10.1093/nar/gky767

Berthelsen, M. F., Thomsen, M. K. & Luo, Y. (2018). Genetically Engineered Pig Models for Human Diseases using ZFNs, TALENs and CRISPR/Cas9. In Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery (pp. 110-131). Cambridge University Press. https://doi.org/10.1017/9781316756300.010

Lin, L., Liu, Y., Xu, F., Huang, J., Daugaard, T. F., Petersen, T. S., Hansen, B., Ye, L., Zhou, Q., Fang, F., Yang, L., Li, S., Fløe, L., Jensen, K. T., Shrock, E., Chen, F., Yang, H., Wang, J., Liu, X. ... Luo, Y. (2018). Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases. GigaScience, 7(3), 1-19. https://doi.org/10.1093/gigascience/giy011

Olagnier, D., Brandtoft, A. M., Gunderstofte, C., Villadsen, N. L., Krapp, C., Thielke, A. L., Laustsen, A., Peri, S., Hansen, A. L., Bonefeld, L., Thyrsted, J., Bruun, V., Iversen, M. B., Lin, L., Artegoitia, V. M., Su, C., Yang, L., Lin, R., Balachandran, S. ... Holm, C. K. (2018). Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. Nature Communications, 9(1), Article 3506. https://doi.org/10.1038/s41467-018-05861-7

Vad-Nielsen, J., Nielsen, A. L. & Luo, Y. (2018). Simple method for assembly of CRISPR synergistic activation mediator gRNA expression array. Journal of Biotechnology, 274, 54-57. https://doi.org/10.1016/j.jbiotec.2018.03.018

Liu, B., Palmfeldt, J., Lin, L., Colaço, A., Clemmensen, K. K. B., Huang, J., Xu, F., Liu, X., Maeda, K., Luo, Y. & Jäättelä, M. (2018). STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH. Cell Research, 28(10), 996–1012. https://doi.org/10.1038/s41422-018-0080-0

Jensen, K. T., Fløe, L., Petersen, T. S., Huang, J., Xu, F., Bolund, L., Luo, Y. & Lin, L. (2017). Chromatin accessibility and guide sequence secondary structure affect CRISPR-Cas9 gene editing efficiency. FEBS Letters, 591(13), 1892-1901. https://doi.org/10.1002/1873-3468.12707

Secher, J., Liu, Y., Petkov, S., Luo, Y., Li, D., Hall, V. J., Schmidt, M., Callesen, H., Bentzon, J. F., Sørensen, C. B., Freude, K. K. & Hyttel, P. (2017). Evaluation of porcine stem cell competence for somatic cell nuclear transfer and production of cloned animals. Animal Reproduction Science, 178, 40-49. https://doi.org/10.1016/j.anireprosci.2017.01.007

Lin, L., Petersen, T. S., Jensen, K. T., Bolund, L., Kühn, R. & Luo, Y. (2017). Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells. Journal of Biotechnology, 247, 42-49. https://doi.org/10.1016/j.jbiotec.2017.02.024

Hussmann, D., Madsen, A. T., Jakobsen, K. R., Luo, Y., Sorensen, B. S. & Nielsen, A. L. (2017). IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells. OncoTarget, 8(20), 33300-33315. https://doi.org/10.18632/oncotarget.16350

Niu, D., Wei, H.-J., Lin, L., George, H., Wang, T., Lee, I.-H., Zhao, H.-Y., Kan, Y., Shrock, E., Lesha, E., Wang, G., Luo, Y., Qing, Y., Jiao, D., Zhao, H., Zhou, X., Wang, S., Wei, H., Güell, M. ... Yang, L. (2017). Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science, 357(6357), 1303-1307. https://doi.org/10.1126/science.aan4187

Toustrup, L. B., Zhou, Y., Kvistgaard, H., Gregersen, N., Rittig, S., Aagaard, L., Corydon, T. J., Luo, Y. & Christensen, J. H. (2017). Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene. Stem Cell Research, 19, 37-42. https://doi.org/10.1016/j.scr.2016.12.021

Zhou, Y., Al-Saaidi, R. A., Guerra, P. F., Freude, K. K., Olsen, R. K. J., Jensen, U. B., Gregersen, N., Hyttel, P., Bolund, L., Aagaard, L., Bross, P. & Luo, Y. (2017). Mitochondrial Spare Respiratory Capacity Is Negatively Correlated With Nuclear Reprogramming Efficiency. Stem Cells and Development, 26(3), 166-176. https://doi.org/10.1089/scd.2016.0162

Zhang, Y., Schmid, B., Nikolaisen, N. K., Rasmussen, M. A., Aldana, B. I., Agger, M., Calloe, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E. ... FReJA Consortium (2017). Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. Stem Cell Reports, 8(3), 648-658. https://doi.org/10.1016/j.stemcr.2017.01.012

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Link to full publications at PURE

https://pure.au.dk/portal/en/persons/alun%40biomed.au.dk

Revised 11.09.2025

Yonglun Luo